Some Information About FSGS You Want to Gain

FSGS (Focal Segmental Glomerulosclerosis) is one of the most common kidney diseases causing renal failure in children and adults. The disease is characterized by scarring in glomeruli; meanwhile, patients’ kidney function declines progressively over time.
The disease attacks more commonly in kids or teenagers, and male patients are more than female ones. Some of FSGS patients suffer from upper respiratory tract infection or allergy before onset. The initial symptom usually presents as Nephrotic Syndrome in clinic. Around 2/3 of those patients lives with massive proteinuria and serious edema. About half of them suffer from blood in urine. Mild and long-standing high blood pressure or chronic nephritic syndrome may attack among 30%-50% of adult patients. In early and middle stage of Focal Segmental Glomerulosclerosis, the albuminuria is usually highly selective, but along with the progression, proteinuria leakage becomes nonselective.
As for the causes of FSGS, poisoning, humoral immunity and changes of haemodynamics could all lead to impairment of capillary wall.
No reliable criterion of FSGS diagnosis, but rule out possible inducing factors such as HIV infections or drug abusing etc. Asking patients’ family history carefully and getting physical and lab examination or tests done are helpful for the diagnosis. Kidney biopsy helps a lot in the diagnosis of Focal Segmental Glomerulosclerosis. The disease is easily to misdiagnose as minimal change disease, so clinical symptoms, biopsy, reaction to steroids and many other factors should be taken into consideration to help diagnose the disease.
There’s no effective treatment for Focal Segmental Glomerulosclerosis in clinic. It is believed that this disease often ends up with a poor prognosis and hard dealing with. Generally, FSGS would progress to ESRD or Renal Failure within 5 to 10 years. In recent years, treating primary cause of Focal Segmental Glomerulosclerosis, applying diuretics, and lowering the high blood pressure could slow down the progression and help get a remission of Nephrotic Syndrome.
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